|
CD8+ cell noncytotoxic anti-HIV response appears to be an anti-HIV innate immune response because it can be observed in vitro with CD8+ cells from unexposed and uninfected healthy individuals. The presence of a CD8+ cell noncytotoxic anti-HIV response (CNAR) was first reported in 1986 by researchers in the laboratory of Dr. Jay Levy at the University of California San Francisco (UCSF).〔 〕 It was recognized that CD8+ cells from HIV-infected individuals can suppress HIV replication without directly killing the infected cells. CNAR was originally hypothesized to be mediated by a CD8+ cell anti-HIV factor (CAF). It is now known that CNAR is mediated by multiple secreted proteins or 'soluble factors', including beta-chemokines (MIP-1 alpha, MIP-1 beta, and RANTES)(3) and type I interferons (interferon alpha and interferon beta)(4). ==References== 3) Science. 1995 Dec 15;270(5243):1811-5. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. 4) J Interferon Cytokine Res. 2013 Nov;33(11):632-45. doi: 10.1089/jir.2012.0067. Epub 2013 Feb 12. CD8(+) lymphocytes suppress human immunodeficiency virus 1 replication by secreting type I interferons. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「CD8+ cell noncytotoxic anti-HIV response」の詳細全文を読む スポンサード リンク
|